Drug interactions may adjust how your medications operate or raise your chance for severe Unintended effects. This doc does not include all feasible drug interactions.
To reduce your threat, your health practitioner should have you take the smallest dose that actually works, and choose it for that shortest probable time. See also Tips on how to Use segment For more info about dependancy.
The concomitant usage of anticholinergic prescription drugs with Promethazine with Codeine Oral Resolution may well raise hazard of urinary retention and/or serious constipation, which may cause paralytic ileus [seeWARNINGS AND Safeguards (five.
The combination of promethazine hydrochloride and codeine phosphate is contraindicated in pediatric individuals less than 6 several years of age, mainly because The mix may trigger fatal respiratory despair With this age populace.
The concomitant use of Promethazine with Codeine Oral Alternative with all cytochrome P450 3A4 inducers or discontinuation of a cytochrome P450 3A4 inhibitor might cause decreased codeine stages, greater norcodeine ranges, and less metabolism via 2D6 with resultant lower morphine amounts.
Hire other supportive steps (like oxygen and vasopressors) from the administration of circulatory shock and pulmonary edema as indicated. Cardiac arrest or arrhythmias would require Superior existence-assist procedures. Gastric emptying might be valuable in eliminating unabsorbed drug.
If somebody has overdosed and it has critical signs such as passing out or issues breathing, connect with 911. Normally, call a poison Manage Heart right away.
Keep in mind that this medication has become prescribed for the reason that your physician has judged that the advantage to you is greater than the risk of Unwanted effects. Many of us using this medication do not need major Negative effects.
If the response to an opioid antagonist is suboptimal or only transient in character, administer supplemental antagonist as directed by the product or service's prescribing information and facts. The respiratory depressant results of promethazine are not reversed by opioid antagonists, which include naloxone. Due to opportunity for promethazine to reverse epinephrine's vasopressor outcome, epinephrine really should not be applied to deal with hypotension related with promethazine overdose.
Psychological dependence, Actual physical dependence, and tolerance may perhaps establish on recurring administration of opioids; therefore, Promethazine with Codeine Oral Answer needs to be prescribed and administered for your shortest duration that's regular with particular person client cure aims and sufferers must be reevaluated just before refills [see Dosage and Administration (two.
Hire other supportive measures (such as oxygen and vasopressors) inside the administration of circulatory shock and pulmonary edema as indicated. Cardiac arrest or arrhythmias would require State-of-the-art daily more info life-guidance approaches. Gastric emptying may very well be valuable in taking away unabsorbed drug.
Shop at place temperature faraway from humidity, heat, and light-weight. Keep an eye on your medication. You have to be informed if anyone is using your drugs improperly or without a prescription.
Don't maintain leftover medication. Examine and punctiliously Keep to the Recommendations presented with this medicine about how to safely eliminate any unused part. Only one dose could potentially cause Loss of life in anyone applying this medicine unintentionally or improperly.
If Promethazine with Codeine Oral Solution is employed for a prolonged interval in the Expecting girl, advise the client of the risk of neonatal opioid withdrawal syndrome and make sure acceptable remedy will probably be out there [see Warnings and Precautions (five.20)].